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Why is this medication prescribed?

Prilosec is prescribed for the short-term treatment (4 to 8 weeks) of stomach ulcer, duodenal ulcer (near the exit from the stomach), and erosive esophagitis (inflammation of the esophagus), and for t he treatment of heartburn and other symptoms of gastroesophageal reflux disease (backflow of acid stomach contents into the canal leading to the stomach). It is also used to maintain healing of erosiv e esophagitis and for the long-term treatment of conditions in which too much stomach acid is secreted, including Zollinger-Ellison syndrome, multiple endocrine adenomas (benign tumors), and systemic mastocytosis (cancerous cells).

Proper Use of This Medicine

Prilosec works best when taken before meals. It can be taken with an antacid.

The capsule should be swallowed whole. It should not be opened, chewed, or crushed.

If you have diffic ulty swallowing capsules, you can empty the contents of the Prilosec capsule onto a tablespoonful of applesauce, mix, and swallow with a glass of cool water. Use cool, soft applesauce and do not chew or crush the pellets. Use the mixture immediately. Do not store it for future use.

Avoid excessive amounts of caffeine while taking this drug.

It may take several days for Prilosec to begin relieving stomach pain. Be sure to continue taking the drug exactly as prescribed even if it seems to have no effect.

Side Effects

Check with your doctor as soon as possible if any of the following side effects occur:

- Back, leg, or stomach pain; bleeding or crusting sores on lips; blisters; bloody or cloudy urine; chills; continuing ulcers or sores in mouth; difficult, burning, or painful urination; fever; frequent urge to urinate; general feeling of discomfort or illness; joint pain; loss of appetite; muscle aches or cramps ; pain; red or irritated eyes; redness, tenderness, itching, burning, or peeling of skin; skin rash or itching; sore throat ; sores, ulcers, or white spots on lips, in mou th, or on genitals; unusual bleeding or bruising ; unusual tiredness or weakness

Symptoms of overdose

Blurred vision; confusion; drowsiness; dryness of mouth; fast or irregular heartbeat; flushing ; general feeling of discomfort or illness; headache; increased sweating; nausea

What special precautions should I follow?

Pregnancy¡XStudies have not been done in humans. However, studies in animals have shown that Prilosec may cause harm to the fetus.

Significant Interactions:

If Prilosec is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Prilosec with the following:

- Ampicillin-containing drugs such as Unasyn
- Cyclosporine (Sandimmune, Neoral)
- Diazepam (Valium)
- Disulfiram (Antabuse)
- Iron
- Ketoconazole (Nizora l)
- Phenytoin (Dilantin)
- Warfarin (Coumadin)


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